产品货号：
Z16799
中文名称：
ERBB3抗体
英文名称：
Anti-ERBB3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ERBB3 Antibody |
| 指标别名 | c erbB 3;c erbB3;ErbB 3;ERBB3;erbB3 S;HER3;LCCS2;MDA BF 1;p180 ErbB3;p45 sErbB3;p85 sErbB3 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | ERBB3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human ErbB 3(162-181aa DWRDIVRDRDAEIVVKDNGR). |
| 实际分子量 | 185KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | ERBB3(V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) also known as ONCOGENE ERBB3 or HER3,is an enzyme that in humans is encoded by the ERBB3 gene.This gene encodes a member of the epidermal growth factor receptor(EGFR) family of receptor tyrosine kinases.This membrane-bound protein has a neuregulin binding domain but not an active kinase domain.By in situ hybridization,Kraus et al.(1989) mapped the ERBB3 gene to chromosome 12q13.Carraway et al.(1994) demonstrated that ERBB3 is a receptor for heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself.Most notably,EGFR and ErbB2 became markedly more promiscuous as the threshold was lowered,whereas ErbB3did not.Engelman et al.(2007) found that amplification of MET caused gefitinib resistance by driving ERBB3-dependent activation of phosphoinositide 3-kinase,a pathway though to be specific to EGFR/ERBB family receptors. |
| Uniprot ID | P21860 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3(avian) |
| 蛋白名全称 | Receptor tyrosine-protein kinase erbB-3 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
相关搜索：ERBB3抗体，ERBB3多抗，Anti-ERBB3 Antibody